High Earnings • OTR, Regional, Local & Dedicated Freight • Consistent Miles and Home Time
View Jobs & Apply Today →Browse the latest CDL-A truck driving opportunities in St. Louis, MO, including OTR, Regional, Local, Dedicated, HazMat, Reefer, Flatbed, and Owner Operator positions. Work with leading carriers, earn competitive weekly pay, and find some of the most reliable freight lanes in the Midwest. Major freight activity runs through downtown St. Louis, the Metro East region, and key logistics corridors near the Mississippi River, Lambert International Airport, and the extensive warehouse districts throughout the metro area.
St. Louis is one of the Midwest’s major transportation and freight gateways, creating steady demand for experienced CDL-A drivers. From long-haul OTR lanes to regional and local delivery routes, drivers benefit from competitive pay, modern trucks, and strong benefits packages. Key freight activity flows through downtown St. Louis, the Metro East logistics corridor, and large distribution areas near the Mississippi River, Lambert International Airport, and surrounding industrial parks. Whether you're looking for dedicated routes, HazMat loads, specialized freight, or owner-operator contracts, St. Louis offers reliable miles and opportunities with top trucking carriers.
Long-haul positions with high pay and consistent miles from major freight hubs.
Regional routes with predictable home time for drivers.
Local routes – home daily with steady routes across metro areas.
Run your own truck with top-tier contracts and freight lanes.
St. Louis, MO is a major Midwestern logistics hub, uniquely positioned along the Mississippi River and intersecting key interstate highways. This provides CDL-A drivers with a combination of local, regional, and OTR opportunities with competitive pay and daily home time for local runs.
Key freight centers in Downtown St. Louis, North County, Westport, and East St. Louis handle large volumes of retail, industrial, and eCommerce freight. Drivers can explore diverse routes and freight types while staying connected to major markets including Chicago, Kansas City, Memphis, and Indianapolis. Learn more about industry trends at Trucking Market News.
Major highways I-70, I-64, I-44, I-55 🛣️ facilitate quick freight movement. With the city’s unique river port logistics and intermodal hubs, St. Louis offers consistent job openings for drivers operating dry van, refrigerated ❄️, flatbed 🏗️, tanker ⚠️, and hazmat freight. Technology innovation in trucking further improves route efficiency: Learn More.
Pay: $1,200+/week (~$32.25/hour)
Local delivery routes with daily home time, operating curtain-side trailers. Day shift, Monday–Friday.
Apply Now →Pay: $1,600–$1,800/week (~$40/hour)
Deliver retail and eCommerce freight with predictable schedules. Sign-on bonus up to $2,000. Consistent home time.
Apply Now →Pay: Up to $0.56/mile
OTR and regional routes across central U.S. states. Freight: Dry van and general commodities. Flexible long-haul and regional shifts.
Apply Now →Pay: $1,450–$1,600/week
OTR routes last 3–7 days with predictable weekly home time across St. Louis, Kansas City, Springfield, Columbia, and Joplin.
Apply Now →Pay: $1,600–$1,950/week
OTR lanes across Midwest, South, and Northeast. Refrigerated freight for regional and long-haul routes. Includes St. Louis and surrounding markets.
Apply Now →Pay: $1,400–$2,100/week
Mostly no-touch flatbed loads including steel, building materials, and machinery. Routes cover St. Louis, Kansas City, Springfield, Joplin, Jefferson City, Rolla.
Apply Now →St. Louis logistics hubs, including intermodal facilities and river ports, handle high-volume freight daily. Drivers transport pallets, containers, and temperature-sensitive shipments for retail, eCommerce, and industrial clients. OTR, regional, and dedicated routes are abundant. Follow Driver Life Updates for trucking news.
Entry-level drivers earn approximately $1,200/week. Experienced drivers on dedicated or specialized freight routes can earn $1,800+ weekly. Bonuses include sign-on incentives, safety rewards, and additional pay for tanker or hazmat endorsements ⚠️. Learn how to maximize earnings with CDL-A School & Job Placement.
Local, regional, OTR, dedicated, flatbed, refrigerated (reefer), tanker, and hazmat positions are available. Select based on endorsements and home-time preferences.
Entry-level drivers can start around $1,200/week. Experienced drivers on dedicated, OTR, or specialized freight may earn $1,600–$1,950/week. Bonuses and incentives are common.
Downtown St. Louis, North County, Westport, East St. Louis, river ports, and intermodal terminals host distribution centers and warehouses for regional and national freight.
Complete the CDL-A Job Application Form. Recruiters will match you with St. Louis and Missouri positions.
Many local and regional routes accept new CDL-A drivers. Specialized freight such as flatbed, tanker, or hazmat generally requires experience and endorsements.
Stay informed via DOT Safety & Regulations.
Top carriers are hiring for OTR, regional, and local routes in St. Louis. Apply now to secure your ideal position and start earning competitive pay.
Apply Now →
